Kelley Laboratory - Cellular and Molecular Sensors

ResearchPeoplePublicationsPositions AvailableShana O. Kelley

Featured Kelley Group Publications:

“Programming the Detection Limits of Biosensors through Controlled Nanostructuring.”  Nature Nanotechnology, and "Profiling of Cancer Biomarkers in Tumour Tissue Using a Multiplexed Nanostructured Microelectrode Integrated Circuit." ACS Nano.

These publications received extensive media coverage and were featured by the National Post, Scientific American, and CBC National News.

rightpublications

    2008 - present

  1. "Targeted Delivery of Doxorubicin to Mitochondria." G. Chamberlain, D.V Tulumello, S.O. Kelley, ACS Chemical Biology, 2013, in press, DOI: 10.1021/cb400095v.

  2. "Optimized Templates for Bottom-Up Growth of High-Performance Integrated Biomolecular Detectors." B. Lam, R.D. Holmes, J. Das, M. Poudineh, A. Sage, E.H. Sargent, S.O. Kelley, Lab on a Chip, 2013, in press, DOI: 10.1039/C3LC41416G.

  3. "Re-directing an Alkylating Agent to Mitochondria Alters Drug Target and Cell Death Mechanism." R. Mourtada, S. B. Fonseca, S.P. Wisnovsky, M.P. Pereira, X. Wang, R. Hurren, J. Parfitt, L. Larsen, R.A.J. Smith, M.P. Murphy, A.D. Schimmer, S.O. Kelley, PLOS One, 2013, 8, e60253.

  4. "Rapid and Specific Electrochemical Detection of Prostate Cancer Cells Using an Aperture Sensor Array." M. Moscovici, A. Bhimji, S.O. Kelley, Lab on a Chip, 2013, 13, 940.

  5. "Chip-Based Nanostructured Sensors Enable Accurate Identification and Classification of Circulating Tumor Cells in Prostate Cancer Patient Blood Samples ." I. Ivanov, J. Stojcic, A. Stanimirovic, E. Sargent, R.K. Nam, S.O. Kelley, Analytical Chemistry, 2013, 85, 398.

  6. "DNA-Based Programming of Quantum Dot Properties." K.B. Cederquist, S.O. Kelley, WIREs: Nanomedicine and Nanobiotechnology, 2013, 5, 86.

  7. "An Ultrasensitve, Universal Detector Based on Neutralizer Displacement." J. Das, K.B. Cederquist, P. Lee, E.H. Sargent, S.O. Kelley, Nature Chemistry, 2012, 4, 642.

  8. "Polymerase Chain Reaction-Free, Sample-to-Answer Bacterial Detection in 30 Minutes with Integrated Cell Lysis." B. Lam, Z. Fang, E.H. Sargent, S.O. Kelley, Analytical Chemistry, 2012, 84, 21.

  9. "Tuning the Activity of Mitochondria-Penetrating Peptides for Delivery or Disruption." K.L. Horton, M.P. Pereira, K.M. Stewart, S.B. Fonseca, S.O. Kelley, Chembiochem, 2012, 13, 476.

  10. "Nanostructured Biomolecular Detectors: Pushing Performance at the Nanoscale." K.B. Cederquist, S.O. Kelley, Current Opinion in Chemical Biology, 2012, 16, 415.

  11. "DNA-Based Programming of Quantum Dot Valency, Self-Assembly, and Luminescence" G. Tikhomirov, S. Hoogland, P.E. Lee, A. Fischer, E.H. Sargent, S.O. Kelley, Nature Nanotechnology, 2011, 6, 485.

  12. "Development of Novel Peptides for Mitochondrial Drug Delivery: Amino Acids Featuring Delocalized Lipophilic Cations" K.M. Stewart, R. Mourtada, S.O. Kelley, Pharmaceutical Research, 2011, 28, 2808.

  13. "Direct Genetic Analysis of Ten Cancer Cells: Tuning Molecular Probe Design for Efficient mRNA Capture" E. Vasilyeva, Z. Fang, M. Minden, E.H. Sargent, S.O. Kelley, Angewandte Chemie, 2011, 50, 4137.

  14. "Hierarchical Nanotextured Microelectrodes Overcome the Molecular Transport Barrier to Achieve Rapid, Direct Bacterial Detection"  L. Soleymani, Z. Fang, B. Lam, X. Bin, E. Vasilyeva, A. Ross, E.H. Sargent, S.O. Kelley, ACS Nano, 2011, 5, 3360.

  15. "Peptide-Chlorambucil Conjugates Combat Pgp-Dependant Drug Efflux" S.B. Fonseca, S.O. Kelley, ACS Medicinal Chemistry Letters, 2011, 2, 419

  16. "Maximizing the Therapeutic Window of an Antimicrobial Drug by Imparting Mitochondrial Sequestration in Human Cells " M.P. Pereira, S.O. Kelley, Journal of the Americal Chemical Society, 2011, 133, 3260.

  17. "Re-routing Chlorambucil to Mitochondria Enhances Potency and Combats Drug Resistance in Cancer Cells " S.B. Fonseca, M.P. Pereira, R. Mourtada, M. Gronda, R. Hurren, M.D. Minden, A.D. Schimmer, S.O. Kelley, Chemistry and Biology, 2011, 18, 445.

  18. "Solvatochromic Reagents for Multicomponent Reactions and their Utility in the Development of Cell-Permeable Macrocyclic Peptide Vectors" B.H.Rotstein, R. Mourtada, S.O. Kelley, A.K. Yudin, Chemistry, 2011, 17, 12257.

  19. "Protein Detection Using Arrayed Microsensor Chips: Tuning Sensor Footprint to Achieve Ultrasensitive Readout of CA-125 in Serum and Whole Blood"  J.Das, S.O. Kelley, Analytical Chemistry, 2011, 83, 1167.

  20. "Nucleic Acid-Passivated Semiconductor Nanocrystals: Biomolecular Templating of Form and Function. "  N. Ma, G. Tikhomirov, S.O. Kelley, Accounts of Chemical Research, 2010, 43, 173.

  21. "Nanostructuring of Sensors Determines the Efficiency of Biomolecular Capture. "  X. Bin, E.H. Sargent, S.O. Kelley, Analytical Chemistry, 2010, 82, 5928.

  22. "The Antiparasitic Agent Ivermectin Induces Chloride-Dependent Membrane Hyperpolarization and Cell Death in Leukemia Cells. "  S. Sharmeen, M. Skrtic, M.A Sukhai, R. Hurren, M. Gronda, X. Wang, S.B. Fonseca, H. Sun, T.E. Wood, R. Ward, M.D. Minden. R. Batey, A. Datti, J. Wrana, S.O. Kelley, A.D. Schimmer, Blood, 2010, 116, 3593.

  23. "Programming the Detection Limits of Biosensors through Controlled Nanostructuring. "  L. Soleymani, Z. Fang, E.H. Sargent, S.O. Kelley, Nature Nanotechnology, 2009, 4, 844.

  24. "Direct, Electronic MicroRNA Detection Reveals Differential Expression Profiles in 30 Minutes. "  H. Yang, A. Hui, G. Pampalakis, L. Soleymani, F.-F. Liu, E. H. Sargent, S.O. Kelley, Angewandte Chemie, 2009, 48, 8461.

  25. "A General Phase-Transfer Protocol for Metal Ions and its Application in Nanocrystal Synthesis. "  J. Yang, E.H. Sargent, S.O. Kelley,* J. Ying* Nature Materials, 2009, 4, 844.

  26. "Direct Profiling of Cancer Biomarkers in Tumour Tissue Using a Multiplexed Nanostructured Microelectrode Integrated Circuit. "  Z. Fang, L. Soleymani, G. Pampalakis, M. Yoshimoto, J.A. Squire, E. H. Sargent, S.O. Kelley, ACS Nano, 2009, 3, 3207.

  27. "Nanostructuring of Patterned Microelectrodes to Enhance the Sensitivity of Electrochemical Nucleic Acids Detection. "  L. Soleymani, X. Sun, H. Yang, B.J. Taft, E. H. Sargent, S.O. Kelley, Angewandte Chemie, 2009, 48, 8457.

  28. "Recent Advances in the Biological and Medical Applications of Cell-Penetrating Peptides." S.B. Fonseca, M. Pereira, S.O. Kelley, Adv. Drug. Del. Rev. 2009, 61, 953.

  29. "One-step Synthesis of DNA-Programmed Semiconductor Nanocrystals."  N. Ma, E.H. Sargent, S.O. Kelley, Nature Nanotechnology, 2009, 4, 121.

  30. "Direct Electrocatalytic mRNA Detection Using PNA-Nanowire Sensors."  Z. Fang, S.O. Kelley, Anal. Chem., 2009, 81, 612.

  31. "An Electrochemical Immunosensor Based on Antibody-Nanowire Conjugtes."  G. Pampalakis, S.O. Kelley, The Analyst, 2009, 134, 447

  32. "Mitochondria-Penetrating Peptides: Sequence Effects and Model Cargo Transport." L. Yousif, K.M. Stewart, K.L. Horton, S.O. Kelley, ChemBioChem, 2009, 10, 2081.

  33. "Engineered Apoptosis-Inducing Peptides with Enhanced Mitochondrial Localization and Potency." K.L. Horton, S.O. Kelley, J. Med. Chem., 2009, 52, 3293.

  34. "Targeting Mitochondria with Organelle-Specific Compounds: Strategies and Applications." L. Yousif, K.M. Stewart, and S.O. Kelley, ChemBioChem, 2009, 10, 1939.

  35. "Potential Use of Cetrimonium Bromide as an Apoptosis-Promoting Anticancer Agent for Head and Neck Cancer.." E. Ito, K.W. Yip D. Katz, S.B. Fonseca, D.W. Hedley, S. Chow, G.W Xu, T.E. Wood, C. Bastianutto, A.D. Schimmer, S.O. Kelley, F.F. Liu, Molecular Pharmacology, 2009, 76, 969.

  36. "Nanomaterials for Ultrasensitive Electrochemical Biosensing." H. Lord, S.O. Kelley, J. Matl. Chem., 2009, 19, 3127.

  37. "Measurement Science: the Engine of Chemical Biology.” Curr. Opin. Chem. Biol. 2008, 12, 473.

  38. "Cell-Permeable Peptides as Delivery Vehicles for Biology and Medicine." K.M. Stewart, K.L. Horton, S.O. Kelley, Org. Biomol. Chem., 2008, 6, 2242.

  39. “Mitochondria-Penetrating Peptides.”  K.L. Horton, K.M. Stewart, S.B. Fonseca, Q. Guo, S.O. Kelley, Chemistry & Biology, 2008, 15, 375. (This article was highlighted by the Faculty of 1000, Nature Methods, and C&E News.)

  40. "A Comparison of Quality of Dispersion of Single Wall Carbon Nanotubes using Different Surfactants and Biomolecules." R. Haggenmueller, s. Rahatekar, J. Fagen, J. Chun, M. Becker, T. Krauss, R. Naik, L. Carlson, J. Kadla, P. Trulove, D. Fox, Z. Fang, S.O. Kelley, J. Gilman*, Langmuir, 2008, 24, 5070.

  41. "Biotemplated Nanostructures: Directed Assembly of Electronic and Optical Materials using NanoscaleComplementarity." N. Ma, E.H. Sargent, S.O.Kelley, J. Mat. Chem., 2008, 18, 954.



    2000-2007

  42. "DNA-Passivated CdS Nanocrystals: Luminescence, Bioimaging, and Toxicity Profiles." N. Ma, J. Yang, K.M. Stewart, S.O. Kelley, Langmuir, 2007, 23, 12783.

  43. "Deconvolution of the Oxidative Stress Response using Organelle-Specific Peptides" K.P. Mahon, T.B. Potocky, D. Blair, M.D. Roy, T.C. Chiles, S.O. Kelley, Chemistry and Biology, 2007, 14, 923.

  44. "Cyanine Dye Conjugates as Probes for Live Cell Imaging." J.R. Carreon, K.M. Stewart, K.P. Mahon, S. Shin, S.O. Kelley, Bioorg. Med. Chem. Lett., 2007, 17, 5182.
  45. "Ultrasensitive Detection of Enzymatic Activity with Nanowire Electrodes." M.A. Roberts, S.O. Kelley, J. Am. Chem. Soc., 2007, 129, 11356.
  46. "NIR-emitting Colloidal Quantum Dots having 26% Luminescence Quantum Yield in Buffer Solution."  S. Hinds, S. Myrskog, L. Levina, G. Koleilat, J. Yang, S.O. Kelley, E.H. Sargent, J. Am. Chem. Soc., 2007, 129, 7218 .
  47. "Nucleotide-Stabilized Cadmium Sulfide Nanoparticles".  C. J. Dooley, J. Rouge, N. Ma, M. Invernale, S.O. Kelley, J. Mat. Chem., 2007, 17, 1687.
  48. "A Single Residue in Leucyl-tRNA Synthetase Affecting Amino Acid Specificity and tRNA Aminoacylation." S.W. Lue and S.O. Kelley, Biochemistry, 2007, 46, 4466.

  49. "Opto-electrical Characteristics of ZnO Nanorods Grown by DNA-Directed Assembly on a Carbon Nanotube Array" A.D. Lazareck, S.G. Cloutier, T.-F. Kuo, B.J. Taft, S.O. Kelley, and J.M. Xu, Applied Physics Letters, 2006, 89, 103109.

  50. "RNA-Templated Semiconductor Nanocrystals." N. Ma, C.J. Dooley, and S.O. Kelley, J. Am. Chem. Soc., 2006, 128, 12598
  51. "Heterogeneous Deposition of Noble Metals on Semiconductor Nanoparticles in Organic or Aqueous Solvents".  J Yang, L. Levina, E. H. Sargent, S. O. Kelley, J. Mat. Chem., 2006, 16, 4025.
  52. "Microfluidic Three-Electrode Cell Array for Low-Current Electrochemical Detection" N. Trirog, M.A. Lapierre-Devlin, S.O. Kelley, and J.R. Beresford, IEEE Sensors, 2006, 128, 1395.
  53. "DNA-Directed Synthesis of Zinc Oxide Nanowires on Carbon Nanotube Tips" A.D. Lazareck, S.G. Cloutier, T.-F. Kuo, B.J. Taft, S.O. Kelley, and J.M. Xu, Nanotechnology, 2006, 17, 2661.
  54. "An Intercalator Monolayer as a DNA-Electrode Interface." B.J. Taft, M.A. Lapierre-Devlin, and S.O. Kelley, Chem. Comm., 2006, 9, 962.
  55. "Programming Nanoparticle Growth using Nucleic Acid Ligands" S. Hinds, B.J. Taft, L. Levina, V. Sukhovatkin, M.D. Roy, C.J. Dooley, M.D. Roy, and E.H. Sargent, and S.O. Kelley, J. Am. Chem. Soc., 2006, 128, 64.
  56. “Tunable DNA Photocleavage by Peptidointercalator Conjugates.”  K.P. Mahon, M.D. Roy, J.R. Carreon, E.G. Prestwich, J. Rouge, S. Shin, and S.O. Kelley, Chem. Bio. Chem., 2006, 7, 766.

  57. "Amplified Electrocatalysis at DNA-Modified Nanowires." M.A. Lapierre-Devlin, R. Gasparac, M.A. Roberts, and S.O. Kelley, Nano Letters, 2005, 5, 1051.

  58. "Oxidative DNA Strand Scission Induced by Peptides.” E.G. Prestwich, M.D. Roy, J. Rego, and S.O. Kelley, Chemistry and Biology, 2005, 12, 695.
  59. "Phototoxicity of Peptidoconjugates Modulated by a Single Amino Acid." L.M. Wittenhagen, J.R. Carreon, E.G. Prestwich, S.O. Kelley, Angew. Chem., 2005, 44, 2542.
  60. "Synthesis, Characterization, and Cellular Uptake of Rose Bengal Peptidoconjugates." J.R. Carreon, M.A. Roberts, L.M. Wittenhagen, and S.O. Kelley, Organic Letters, 2005, 7, 99.
  61. "Solution Structure of a Pathogenic tRNA Mutant." M.D. Roy, L.M. Wittenhagen, and S.O. Kelley, RNA, 2005, 11, 254.
  62. "A Human Aminoacyl-tRNA Synthetase with a Defunct Editing Site." S.W. Lue and S.O. Kelley, Biochemistry, 2005, 44, 3010.
  63. "Combinatorial Analysis of tRNA Substrates for hs mt LeuRS." E. Zagriadska and S.O. Kelley, Biochemistry, 2005, 44, 233.
  64. "Ultrasensitive Electrocatalytic DNA Detection with 3D Nanoelectrodes." R.L. Gasparac, B.J. Taft. and S.O. Kelley, J. Am. Chem. Soc., 2004, 126, 12270.
  65. "Site-Specific Delivery of DNA and Appended Cargo to Arrayed Carbon Nanotubes." B.J. Taft, A. Lazareck, J.M. Xu, and S.O. Kelley, J. Am. Chem. Soc., 2004, 126, 12750.
  66. "Interdomain Communication in a Disease-Related Human tRNA." M.D. Roy, L.M. Wittenhagen, and S. O. Kelley, Biochemistry, 2004, 43, 384.
  67. "Thiazole Orange-Peptide Conjugates: Sensitivity of DNA Binding to Chemical Structure." K.P. Mahon, J.R. Carreon, and S.O. Kelley, Organic Letters, 2004, 6, 517.
  68. "Impact of Disease-Related Mitochondrial Mutations on tRNA Structure and Function." L.M. Wittenhagen and S.O. Kelley, Trends in Biochemical Sciences, 2003, 28, 605.
  69. "The Pathogenic U3271C Human Mitochondrial tRNALeu(UUR) Mutation Disrupts a Fragile Anticodon Stem." L.M. Wittenhagen, M.D. Roy, and S.O. Kelley, Nucl. Acids Res., 2003, 2, 596.
  70. "Engineering DNA-Electrode Connectivities: Manipulation of Linker Length and Structure." B. Taft, M. O'Keefe, J. Fourkas, and S.O. Kelley, Anal. Chim. Acta., 2003, 496, 81.
  71. "Electrocatalytic Detection of Pathogenic DNA Sequences." M.A. Lapierre, M.M. O'Keefe, B.J. Taft, and S. O. Kelley, Anal. Chem., 2003, 75, 632.
  72. "Photosensitized DNA Cleavage Promoted by Amino Acids." K.P. Mahon, R.F. Ortiz Meoz, and S. O. Kelley, Chem. Comm., 2003, 15, 1956.
  73. "Charge Migration Through Double Helical DNA." S.O. Kelley in Electroanalytical Methods for Biological Materials, Marcel Dekker, NY, 2002.
  74. "Dimerization of a Pathogenic Human tRNA." L.M. Wittenhagen and S.O. Kelley, Nat. Struct. Biol., 2002, 9, 586.



    Graduate and postdoctoral publications

  75. "Intercalative Stacking: A Critical Feature of DNA Charge-Transport Electrochemistry." E.M. Boon, N.M. Jackson, M.D. Wightman, S.O. Kelley, M.G. Hill, and J.K. Barton, J. Phys. Chem. B., 2003, 107, 11805.
  76. "Synthesis and Spectroelectrochemistry of Ir(bpy)(phen)(phi)3+." C.S. Stinner, M.D. Wightman, S.O. Kelley, M.G. Hill, J.K. Barton, Inorg. Chem., 2001, 40, 5245.
  77. "Fragile T-stem in Disease-associated Human Mitochondrial tRNA Sensitizes Structure to Local and Distant Mutations." S.O. Kelley, S.V. Steinberg, and P. Schimmel, J. Biol. Chem., 2001, 276, 10607.
  78. "Exiting an RNA World." P. Schimmel and S.O. Kelley, Nat. Struct. Biol., 2000, 7, 5.
  79. "Pathogenic Functional Defects of a Mitochondrial tRNA Related to Structural Fragility." S.O. Kelley, S. V. Steinberg, and P. Schimmel, Nat. Struct. Biol., 2000, 7, 862.
  80. "Electron Transfer between Bases in Double Helical DNA." S.O. Kelley and J.K. Barton, Science 1999, 283, 375-383.
  81. "Long-Range Electron Transfer Through DNA Monolayers." S.O. Kelley, N.M. Jackson, M.G. Hill, and J.K. Barton, Angew. Chem. Intl. Ed. Eng., 1999, 38, 941.
  82. "Femtosecond Dynamics of the DNA Intercalator Ethidium and Electron Transfer with Mononucleotides." T. Fiebig, C. Wan, S.O. Kelley, J.K. Barton, A. Zewail, Proc. Natl. Acad. Sci., U.S.A. 1999, 96, 1187.
  83. "Femtosecond Dynamics of DNA-Mediated Electron Transfer." T. Fiebig, S.O. Kelley, C. Wan, C. R. Treadway, J.K. Barton, A. Zewail, Proc. Natl. Acad. Sci., U.S.A., 1999, 96, 6014.
  84. "Single-Base Mismatch Detection Based on Charge Transduction Through DNA." S.O. Kelley, E.M. Boon, N.M. Jackson, M.G. Hill, and J.K. Barton, Nucl. Acids Res., 1999, 27, 4830.
  85. "DNA-Mediated Electron Transfer from Ethidium to a Modified Base." S.O. Kelley and J.K. Barton, Chem. Biol., 1998, 8, 413.
  86. "Radical Migration Through the DNA Helix: Chemistry at a Distance." S.O. Kelley and J.K. Barton, Metal Ions Biol. Sys., 1998, 26, 211.
  87. "Long-Range and Short-Range Oxidative Damage to DNA: Photoinduced Damage to Guanines in Ethidium-DNA Assemblies." D.B. Hall, S.O. Kelley, J.K. Barton, Biochemistry, 1998, 37, 15933.
  88. "Orienting DNA Helices on Gold Using Applied Fields." S.O. Kelley, J. K. Barton, N.M. Jackson, L. MacPherson, A. Potter, E.M. Spain, M.J. Allen, and M.G. Hill, Langmuir, 1998, 14, 6781.
  89. "Electrochemistry of Methylene Blue Bound to a DNA-Modified Electrode." S.O. Kelley, J. K. Barton, N.M. Jackson, and M. Hill, Bioconj. Chem., 1997, 8, 31.
  90. "Photoinduced Electron Transfer in Ethidium-Modified Duplexes." S.O. Kelley, R.E. Holmlin, E.D.A. Stemp, and J.K. Barton, J. Am. Chem. Soc., 1997, 119, 9861.